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Adjusted risks were highest among older recipients, increased with time since transplantation, and varied by organ type (all ≤ .007).
Azathioprine, cyclosporine, and m TOR inhibitors given for maintenance immunosuppression increased risk, and non-Hispanic white recipients on cyclosporine and azathioprine experienced increasing MCC risk with lower latitude of residence (ie, higher ultraviolet radiation exposure, MCC risk is sharply elevated after solid organ transplant, likely resulting from long-term immunosuppression.
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Solid organ transplant recipients have elevated risks of virus-related cancers, in part because of long-term immunosuppression.
Merkel cell carcinoma (MCC) is an aggressive skin cancer recently found to have a viral origin, but little is known regarding the occurrence of MCC after transplant.